AKIYAMA Yoshikatsu
   Department   Research Institutes and Facilities, Research Institutes and Facilities
   Position   Assistant Professor
Language English
Category Chapter contribution
Title 5.35 - Biomaterials: Temperature-Responsive Polymer
Book title Comprehensive Biotechnology
ISBN 978-0-444-64047-5
Editor Murray Moo-Young
Edition, Volume, Page 3rd,5,pp.457-470
Total page number 4870
Publication place
(City and country)
Oxford, UK
Author and coauthor KOBAYASHI Jun, AKIYAMA Yoshikatsu, YAMATO Masayuki, OKANO Teruo
Publication date 2019/07
Summary Temperature-responsive polymers are used as switching sequences to regulate interfacial phenomena and initiate unique biomedical and biotechnological applications. Special attention has been paid to poly(N-isopropylacrylamide) (PIPAAm), which exhibits a reversible temperature-dependent phase transition in aqueous solutions at the lower critical solution temperature (LCST) of 32 °C. Soluble and cross-linked PIPAAm undergo temperature-responsive dynamic volume changes, which are utilized for regulating on–off drug release and mimicking biological functions. However, no clinical studies on implantation of PIPAAm-based biomaterials have been reported. By contrast, PIPAAm-modified intelligent surfaces, which exhibit hydrophilic/hydrophobic alteration in response to temperature change, are readily adaptive to clinical applications because no PIPAAm molecules are eluted in the solution during the interaction with biological materials. The PIPAAm-immobilized surfaces achieve purifying bioactive molecules in aqueous media and recovering cell sheets to create three dimensional tissues for regeneration of damaged tissues only by changing temperature.