コバヤシ　ジユン   Kobayashi Jiyun   小林　純    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   講師
言語種別	英語
種別	部分執筆
表題	5.35 - Biomaterials: Temperature-Responsive Polymer
書名	Comprehensive Biotechnology
ISBNコード	978-0-444-64047-5
編者名	Murray Moo-Young
版・巻・頁	3rd,5,pp.457-470
総ページ数	4870
出版社	Elsevier
出版地 （都市, 国名）	Oxford, UK
著者・共著者	KOBAYASHI Jun, AKIYAMA Yoshikatsu, YAMATO Masayuki, OKANO Teruo
発行年月	2019/07
概要	Temperature-responsive polymers are used as switching sequences to regulate interfacial phenomena and initiate unique biomedical and biotechnological applications. Special attention has been paid to poly(N-isopropylacrylamide) (PIPAAm), which exhibits a reversible temperature-dependent phase transition in aqueous solutions at the lower critical solution temperature (LCST) of 32 °C. Soluble and cross-linked PIPAAm undergo temperature-responsive dynamic volume changes, which are utilized for regulating on–off drug release and mimicking biological functions. However, no clinical studies on implantation of PIPAAm-based biomaterials have been reported. By contrast, PIPAAm-modified intelligent surfaces, which exhibit hydrophilic/hydrophobic alteration in response to temperature change, are readily adaptive to clinical applications because no PIPAAm molecules are eluted in the solution during the interaction with biological materials. The PIPAAm-immobilized surfaces achieve purifying bioactive molecules in aqueous media and recovering cell sheets to create three dimensional tissues for regeneration of damaged tissues only by changing temperature.