ムラガキ　ヨシヒロ   Muragaki Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
言語種別	英語
種別	部分執筆
表題	Management of non-benign meningiomas with Gamma Knife radiosurgery
書名	Gamma Knife Neurosurgery in the Management of Intracranial Disorders
ISBNコード	9783709113752
編者名	Mikhail Chernov,Motohiro Hayashi,Jeremy Ganz,Kintomo Takakura
版・巻・頁	116,pp.91-97
出版社	Springer-Verlag Wien
出版地 （都市, 国名）	Austria
著者・共著者	TAMURA Manabu, KUBO Kenji , OKITA Ryuji, OGURA Mitsuhiro, NAKAO Naoyuki, UEMATSU Yuji, ITAKURA Toru, HAYASHI Motohiro, MURAGAKI Yoshihiro, ISEKI Hiroshi
発行年月	2013/03
概要	Results of Gamma Knife radiosurgery (GKS) were retrospectively evaluated in 16 patients with histologically confirmed atypical and anaplastic intracranial meningiomas.|There were nine men and seven women (mean age 61.0 years). Atypical meningiomas were diagnosed in nine cases and anaplastic meningiomas in seven. In nine patients there was malignant transformation of a tumor that had initially proved to be benign. In total, 21 radiosurgical procedures were performed. The mean tumor volume at the time of GKS was 7.1 cm3. The mean marginal and maximum irradiation doses were 18.8 and 37.0 Gy, respectively. The mean length of follow-up after treatment was 37.1 months.|Of 21 radiosurgical procedures, 6 (29 %) led to stabilization of tumor growth during the mean follow-up of 40.5 months. It was significantly associated with small lesion volume (P = 0.02), and greater marginal (P = 0.04) and maximum (P = 0.02) irradiation doses. Seven patients underwent eight surgical resections of a progressing tumor during the mean period of 26.1 months after irradiation. Five patients (31 %) died because of tumor progression within the average time period of 16.8 months after GKS. Overall, at the time of the last follow-up just two patients (13 %) had no evidence of tumor regrowth, and only three patients (19 %) maintained good activities of daily living during 12, 59, and 69 months, respectively, after radiosurgery.|GKS has limited efficacy in cases of non-benign meningioma. Better tumor control rates can be attained for small neoplasms treated with greater marginal and maximum irradiation doses