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NAKABAYASHI Akira
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Outcomes of Ovulation Induction Aimed to Pregnancy in Eight Hypopituitarism Patients. |
| Journal | Formal name：Cureus Abbreviation：Cureus ISSN code：21688184/21688184 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 16(4),pp.e58819 |
| Author and coauthor | Horibe Yu, Nakabayashi Akira, Murata Shuko, Hashimoto Tomomi, Tabata Tsutomu |
| Publication date | 2024/04 |
| Summary | BACKGROUND:Female sex hormones work in concert. Gonadotropin-releasing hormone and ovulation-inducing agents are required in female patients with infertility owing to hormone dysregulation. Although drug-induced follicular development can be expected in patients with endogenous female hormone deficiency, data are lacking on the protocols and drugs used.METHODS:We retrospectively examined the success rates of ovulation induction, assisted reproductive technology, and pregnancy outcomes in 66 cycles of eight patients with pituitary insufficiency at our hospital.RESULTS:Ovulation occurred in 75.4% (49/66); 82.6% (38/46) of patients <40 years and 57.9% (11/19) of patients ≥40 years of age. Five of the eight patients became pregnant, and three delivered babies. The fertilization rate was 78% with in vitro fertilization, and the recombinant follicle-stimulating hormone usage was 3,717.1 ± 1,528.9 International Unit in hypopituitarism patients.CONCLUSION:Hypopituitarism patients can achieve ovulation, pregnancy, and delivery after optimal gonadotropin administration. Further studies are needed to determine the effects of gonadotropins on other pituitary hormones, such as growth hormones. |
| DOI | 10.7759/cureus.58819 |
| PMID | 38784333 |