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SAITOU Satoshi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | Chronic Inflammatory Demyelinating Polyradiculoneuropathy with Diplopia Caused by an Alternative Coronavirus Disease 2019 Vaccine. |
| Journal | Formal name：Case reports in neurological medicine Abbreviation：Case Rep Neurol Med ISSN code：20906668/20906676 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 2024,pp.8584482 |
| Author and coauthor | Saito Satoshi, Iijima Mutsumi, Seki Misa, Shimomura Ayato, Kitagawa Kazuo |
| Authorship | Lead author |
| Publication date | 2024 |
| Summary | The etiology of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) remains elusive and is believed to involve multiple contributing factors. There have been cases linking CIDP to the coronavirus disease 2019 (COVID-19) mRNA vaccine. However, there are no documented instances following alternative vaccines. We report a case of a 48-year-old woman, previously vaccinated with Pfizer-BioNTech's COVID-19 vaccine (BNT162b2), who subsequently received the Moderna mRNA-1273 vaccine. Within 2 days postvaccination, she developed diplopia and numbness in the lower limbs' distal extremities. Cerebrospinal fluid analysis exhibited protein-cell dissociation, while F-wave studies showed demyelinating activity in the bilateral tibial nerves. Given the disease's progressive nature, the patient was presumed to have CIDP and commenced steroid pulse therapy and intravenous immunoglobulin therapy. The onset of CIDP may be associated with variations in mRNA sequences and vaccine constituents. |
| DOI | 10.1155/2024/8584482 |
| PMID | 38939233 |