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SATOU Kiyouko
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | The effect of donepezil treatment on cardiovascular mortality. |
| Journal | Formal name：Clinical pharmacology and therapeutics Abbreviation：Clin Pharmacol Ther ISSN code：(1532-6535)0009-9236(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 88(3),pp.335-8 |
| Author and coauthor | Sato K, Urbano R, Yu C, Yamasaki F, Sato T, Jordan J, Robertson D, Diedrich A |
| Authorship | Lead author |
| Publication date | 2010/09 |
| Summary | The acetylcholinesterase inhibitor donepezil hydrochloride improves cognitive function in patients with Alzheimer's disease and vascular dementia. Given acetylcholine's important actions on the heart, we undertook a retrospective cohort investigation to assess whether donepezil usage affects cardiovascular mortality. In patients treated with donepezil, hazard ratios for total and cardiovascular mortality were 0.68 (P = 0.045, 95% confidence interval 0.46-0.99) and 0.54 (P = 0.042, 95% confidence interval 0.30-0.98), respectively. The apparent survival benefit in donepezil-treated patients should not be overinterpreted. Prospective clinical trials are warranted. |
| DOI | 10.1038/clpt.2010.98 |
| PMID | 20664535 |