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SATOU Kiyouko
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Distal sudomotor findings in postural tachycardia syndrome. |
| Journal | Formal name：Clinical autonomic research : official journal of the Clinical Autonomic Research Society Abbreviation：Clin Auton Res ISSN code：1619-1560(Electronic)0959-9851(Linking) |
| Volume, Issue, Page | 20(2),pp.93-9 |
| Author and coauthor | Peltier Amanda Catherine, Garland Emily, Raj Satish R, Sato Kyoko, Black Bonnie, Song Yanna, Wang Lily, Biaggioni Italo, Diedrich Andre, Robertson David |
| Publication date | 2010/04 |
| Summary | OBJECTIVES:Postural tachycardia syndrome (POTS) is a heterogeneous disorder characterized by excessive orthostatic tachycardia in the absence of orthostatic hypotension and by sympathetic nervous system activation. Postganglionic sudomotor deficits have been used to define a neurogenic postural tachycardia POTS subtype. Norepinephrine levels aboveOBJECTIVES:600 pg/ml have also been used to delineate patients with a hyperadrenergic state. This study aims to determine the relationship of sudomotor abnormalities to other aspects of dysautonomia in POTS.METHODS:Autonomic function was quantified in thirty women through tests of cardiovagal, adrenergic, and sudomotor function including quantitative sudomotor axon reflex testing (QSART) and spectral indices. Differences between patients with and without sudomotor dysfunction as defined by QSART and between patients with and without hyperadrenergic POTS were assessed with Mann-Whitney U test and Mantel-Haenszel Chi-Square test using a p value of 0.01 for significance. Spearman correlation coefficients were used to test raw sweat volume correlations with other variables.RESULTS:Of 30 women (ages 20-58), 17 patients (56%) had an abnormal QSART which was typically patchy and involved the lower extremity, while 13 patients had normal QSART results. Other autonomic tests, catecholamines or spectral indices did not correlate with QSART results. No differences in autonomic tests or spectral indices were observed between hyperadrenergic and non-hyperadrenergic POTS.INTERPRETATION:Our findings confirm that a large subset of POTS patients have sudomotor abnormalities which are typically patchy in distribution but do not correlate with other tests of autonomic function. Further studies are needed to determine the best method of endophenotyping patients with POTS. |
| DOI | 10.1007/s10286-009-0045-y |
| Document No. | 20035362 |