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SATOU Kiyouko
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Long-term prognosis of dilated cardiomyopathy revisited: an improvement in survival over the past 20 years. |
| Journal | Formal name：Circulation journal : official journal of the Japanese Circulation Society Abbreviation：Circ J ISSN code：1346-9843(Print)1346-9843(Linking) |
| Volume, Issue, Page | 70(4),pp.376-83 |
| Author and coauthor | Matsumura Yoshihisa, Takata Jun, Kitaoka Hiroaki, Kubo Toru, Baba Yuichi, Hoshikawa Eri, Hamada Tomoyuki, Okawa Makoto, Hitomi Nobuhiko, Sato Kyoko, Yamasaki Naohito, Yabe Toshikazu, Furuno Takashi, Nishinaga Masanori, Doi Yoshinori |
| Publication date | 2006/04 |
| Summary | BACKGROUND:Because of their favorable prognostic effects, angiotensin converting enzyme inhibitors (ACEI), angiotensin II receptor blockers (ARB) and beta blockers have become background therapy in dilated cardiomyopathy (DCM). However, there are few reports concerning the long-term prognosis of Japanese patients with DCM in relation to these treatments.METHODS AND RESULTS:One hundred and fifty patients with DCM were divided into 2 groups: group A (n=46) (diagnosis: 1982-1989) and group B (n=104) (diagnosis: 1990-2002). During follow-up period of 6.9+/-4.8 years, 62 patients died and 1 patient had a heart transplant. The survival rate at 5 and 10 years was 60.9% and 34.8%, respectively, in group A patients, and 80.9% and 65.3%, respectively, in group B patients (p=0.0079). In group A patients, ACEI/ARB or beta blockers were less frequently used (pMETHODS AND RESULTS:<METHODS AND RESULTS:0.0001), whereas antiarrhythmics (class Ia or Ib) were more often used (pMETHODS AND RESULTS:<METHODS AND RESULTS:0.0001). The patients treated with ACEI/ARB and beta blockers showed a better survival rate than those without (pMETHODS AND RESULTS:<METHODS AND RESULTS:0.0001). The patients with antiarrhythmics showed a worse survival rate than those without (pMETHODS AND RESULTS:<METHODS AND RESULTS:0.0001).CONCLUSION:The prognosis of Japanese patients with DCM has significantly improved over the past 20 years. This improvement may be explained partly through the increased use of ACEI/ARB and beta blockers and a declining use of antiarrhythmics. |
| Document No. | 16565551 |