|
TAKAYAMA Yukiko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
|
| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | 5-Fluorouracil metabolic pathway genes predict recurrence risk following adjuvant S-1 therapy: Results of an ancillary analysis from a phase III trial of resected biliary tract cancer (JCOG1202A1) |
| Journal | Formal name：Journal of hepato-biliary-pancreatic sciences Abbreviation：J Hepatobiliary Pancreat Sci ISSN code：18686982/18686974 |
| Domestic / Foregin | Domestic |
| Volume, Issue, Page | 31(12),pp.886-896 |
| Author and coauthor | MITSUNAGA Shuichi, IKEDA Masafumi, NOMURA Shogo, MORIZANE Chigusa, TODAKA Akiko, YAMAMOTO Naoto, KAMATA Ken, YANAGIBASHI Hiroo, MIZUNO Nobumasa, KAWAMOTO Yasuyuki, GOTOH Kunihito, SHIRAKAWA Hirofumi, OKANO Naohiro, NOMURA Tatsuya, TANAKA Kazunari, TAKAHASHI Amane, YAGI Shintaro, OHTA Koji, TAKAYAMA Yukiko, MIWA Haruo, NAGANO Hiroaki, KOJIMA Yasushi, HISANO Terumasa, TAHARA Munenori, SAKUMA Yasunaru, ARAI Hiroyuki, NAKAMURA Ikuo, KATAYAMA Hiroshi, KONISHI Masaru, UENO Makoto |
| Publication date | 2024/12 |
| Summary | BACKGROUND:S-1, an oral fluoropyrimidine derivative, is standard adjuvant therapy for resected biliary tract cancer (BTC), based on the results of the JCOG1202, a phase III trial evaluating the survival benefit with adjuvant S-1 following curative resection for BTC compared to surgery alone. This multicenter ancillary study of the JCOG1202 aimed to evaluate the prognostic impact of the 5-fluorouracil (5-FU) metabolic pathway genes including thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD).METHODS:The 5-FU metabolic pathway genes were measured in tumor cells from formalin-fixed paraffin-embedded resected specimens from 183 patients (surgery alone: n = 94; adjuvant S-1: n = 89). We randomly divided them into training (n = 96) and validation sets (n = 87) for evaluating the interaction between gene levels and RFS benefits in the treatment arm.RESULTS:RFS benefits of adjuvant S-1 were observed in the low DPD (HR = 0.440 and 0.748, respectively in the training and validation sets) and the low TP groups (HR = 0.709 and 0.602, respectively). Clinicopathological characteristics were well balanced between low and high DPD populations. More advanced stage tumors were observed in high TP populations as compared to those in low TP populations (p = .0332).CONCLUSION:The results suggest the RFS benefit of adjuvant S-1 in resected BTC patients with low DPD and low TP gene expressions. |
| DOI | 10.1002/jhbp.12071 |
| PMID | 39318258 |