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MATSUMOTO Etsuko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | SARS-CoV-2 co-detection with other respiratory pathogens-descriptive epidemiological study. |
| Journal | Formal name：Respiratory investigation Abbreviation：Respir Investig ISSN code：22125353/22125345 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 62(5),pp.884-888 |
| Author and coauthor | Arimura Ken†, Kikuchi Ken, Sato Yasuto, Miura Hitomi, Sato Asako, Katsura Hideki, Kondo Mitsuko, Itabashi Michio, Tagaya Etsuko |
| Publication date | 2024/09 |
| Summary | BACKGROUND:Co-detection of respiratory pathogens with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is poorly understood. This descriptive epidemiological study aimed to determine the effect of the interaction of different respiratory pathogens on clinical variables.METHODS:We retrospectively reviewed the results of comprehensive multiplex polymerase chain reaction (PCR) testing from November 2020 to March 2023 to estimate respiratory pathogen co-detection rates in Shinjuku, Tokyo. We evaluated the interactions of respiratory pathogens, particularly SARS-CoV-2, between observed and expected co-detection. We estimated the trend of co-detection with SARS-CoV-2 in terms of age and sex and applied a multiple logistic regression model adjusted for age, testing period, and sex to identify influencing factors between co-detection and single detection for each pathogen.RESULTS:Among 57,746 patients who underwent multiplex PCR testing, 10,516 (18.2%) had positive for at least one of the 22 pathogens. Additionally, 881 (1.5%) patients were confirmed to have a co-detection. SARS-CoV-2 exhibited negative interactions with adenovirus, coronavirus, human metapneumovirus, parainfluenza virus, respiratory syncytial virus, and rhino/enterovirus. SARS-CoV-2 co-detection with other pathogens occurred most frequently in patients of the youngest age group (0-4 years). A multiple logistic regression model indicated that younger age was the most influential factor for SARS-CoV-2 co-detection with other respiratory pathogens.CONCLUSION:The study highlights the prevalence of SARS-CoV-2 co-detection with other respiratory pathogens in younger age groups, necessitating further exploration of the clinical implications and severity of SARS-CoV-2 co-detection. |
| DOI | 10.1016/j.resinv.2024.07.016 |
| PMID | 39098246 |