金井 貴幸
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | The impact of 4DCT-ventilation imaging-guided proton therapy on stereotactic body radiotherapy for lung cancer. |
Journal | Formal name:Radiological physics and technology Abbreviation:Radiol Phys Technol ISSN code:18650341/18650333 |
Domestic / Foregin | Domestic |
Volume, Issue, Page | 13(3),pp.230-237 |
Author and coauthor | Ieko Yoshiro, Kadoya Noriyuki, Kanai Takayuki, Nakajima Yujiro, Arai Kazuhiro, Kato Takahiro, Ito Kengo, Miyasaka Yuya, Takeda Ken, Iwai Takeo, Nemoto Kenji, Jingu Keiichi |
Publication date | 2020/09 |
Summary | Functional lung avoidance during radiotherapy can help reduce pulmonary toxicity. This study assessed the potential impact of four-dimensional computed tomography (4DCT)-ventilation imaging-guided proton radiotherapy (PT) on stereotactic body radiotherapy (SBRT) by comparing it with three-dimensional conformal radiotherapy (3D-CRT) and volumetric modulated arc therapy (VMAT), which employ photon beams. Thirteen lung cancer patients who received SBRT with 3D-CRT were included in the study. 4DCT ventilation was calculated using the patients' 4DCT data, deformable image registration, and a density-change-based algorithm. Three functional treatment plans sparing the functional lung regions were developed for each patient using 3D-CRT, VMAT, and PT. The prescribed doses and dose constraints were based on the Radiation Therapy Oncology Group 0618 protocol. We evaluated the region of interest (ROI) and functional map-based dose-function metrics for 4DCT ventilation and the irradiated dose. Using 3D-CRT, VMAT, and PT, the percentages of the functional lung regions that received ≥ 5 Gy (fV5) were 26.0%, 21.9%, and 10.7%, respectively; the fV10 were 14.4%, 11.4%, and 9.0%, respectively; and fV20 were 6.5%, 6.4%, and 6.6%, respectively, and the functional mean lung doses (fMLD) were 5.6 Gy, 5.2 Gy, and 3.8 Gy, respectively. These results indicated that PT resulted in a significant reduction in fMLD, fV5, and fV10, but not fV20. The use of PT reduced the radiation to highly functional lung regions compared with those for 3D-CRT and VMAT while meeting all dose constraints. |
DOI | 10.1007/s12194-020-00572-5 |
PMID | 32537735 |