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瀧澤 光太郎
Department School of Medicine, School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Distribution of mRNA for GPR143, a receptor of 3,4-L-dihydroxyphenylalanine, and of immunoreactivities for nicotinic acetylcholine receptors in the nigrostriatal and mesolimbic regions. |
| Journal | Formal name：Neuroscience research Abbreviation：Neurosci Res ISSN code：18728111/01680102 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 170,pp.370-375 |
| Author and coauthor | Kasahara Yuka, Masukawa Daiki, Nakamura Yoshie, Murata Koshi, Hashimoto Tatsuo, Takizawa Kohtaro, Koga Motokazu, Nakamura Fumio, Fukazawa Yugo, Funakoshi Kengo, Goshima Yoshio |
| Publication date | 2020/09/05 |
| Summary | Nicotine exerts its reinforcing actions by activating nicotinic acetylcholine receptors (nAChRs), but the detailed mechanisms remain unclear. Nicotine releases 3, 4-dihydroxyphenylalanine (DOPA), a neurotransmitter candidate in the central nervous system. Here, we investigated the distribution of GPR143, a receptor of DOPA, and nAChR subunits in the nigrostriatal and mesolimbic regions. We found GPR143 mRNA-positive cells in the striatum and nucleus accumbens. Some of them were surrounded by tyrosine hydroxylase (TH)-immunoreactive fibers. There were some GPR143 mRNA-positive cells coexpressing TH, and nAChR subunit α4 or α7 in the substantia nigra and ventral tegmental area. These findings suggest that DOPA-GPR143 signaling may be involved in the nicotine action in the nigrostriatal and mesolimbic dopaminergic systems. |
| DOI | 10.1016/j.neures.2020.08.003 |
| PMID | 32896531 |