廣島 健三
Department Other, Other Position |
|
Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Significance of the correlation between the expression of interleukin 6 and clinical features in patients with non-small cell lung cancer. |
Journal | Formal name:International journal of surgical pathology Abbreviation:Int J Surg Pathol ISSN code:1940-2465(Electronic)1066-8969(Linking) |
Volume, Issue, Page | 20(3),pp.233-9 |
Author and coauthor | Koh Eitetsu†, Iizasa Toshihiko, Yamaji Haruko, Sekine Yasuo, Hiroshima Kenzo, Yoshino Ichiro, Fujisawa Takehiko |
Publication date | 2012/06 |
Summary | BACKGROUND:The aims of the study were to identify the significance of interleukin (IL)-6 production and to determine whether IL-6 production influences long-term survival in patients with non-small-cell lung cancer (NSCLC).METHOD:A series of 90 patients with NSCLC who underwent surgery between 2005 and 2007 was analyzed. Preoperative serum IL-6 was measured, and tumor samples were immunohistochemically stained for IL-6.RESULTS:Serum IL-6 levels were elevated in 43 of 90 cases (47.7%), and 23 (25.5%) of 90 cases stained positively for IL-6 (P = .00265). The prognosis of patients with NSCLC who had positive immunohistochemical staining was significantly worse than that for those who had negative staining, by univariate analysis (P = .0027). Multivariate analysis indicated that tumor size, postoperative stage, and overexpression of IL-6 were independent prognostic factors.CONCLUSIONS:The expression of IL-6 in tumor correlated with the concentration of serum IL-6, tumor progression, and overall survival in patients with NSCLC. |
DOI | 10.1177/1066896911436274 |
Document No. | 22334615 |