ヒロシマ ケンゾウ
廣島 健三 所属 その他 その他 職種 登録医 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Significance of the correlation between the expression of interleukin 6 and clinical features in patients with non-small cell lung cancer. |
掲載誌名 | 正式名:International journal of surgical pathology 略 称:Int J Surg Pathol ISSNコード:1940-2465(Electronic)1066-8969(Linking) |
巻・号・頁 | 20(3),pp.233-9 |
著者・共著者 | Koh Eitetsu†, Iizasa Toshihiko, Yamaji Haruko, Sekine Yasuo, Hiroshima Kenzo, Yoshino Ichiro, Fujisawa Takehiko |
発行年月 | 2012/06 |
概要 | BACKGROUND:The aims of the study were to identify the significance of interleukin (IL)-6 production and to determine whether IL-6 production influences long-term survival in patients with non-small-cell lung cancer (NSCLC).METHOD:A series of 90 patients with NSCLC who underwent surgery between 2005 and 2007 was analyzed. Preoperative serum IL-6 was measured, and tumor samples were immunohistochemically stained for IL-6.RESULTS:Serum IL-6 levels were elevated in 43 of 90 cases (47.7%), and 23 (25.5%) of 90 cases stained positively for IL-6 (P = .00265). The prognosis of patients with NSCLC who had positive immunohistochemical staining was significantly worse than that for those who had negative staining, by univariate analysis (P = .0027). Multivariate analysis indicated that tumor size, postoperative stage, and overexpression of IL-6 were independent prognostic factors.CONCLUSIONS:The expression of IL-6 in tumor correlated with the concentration of serum IL-6, tumor progression, and overall survival in patients with NSCLC. |
DOI | 10.1177/1066896911436274 |
文献番号 | 22334615 |