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本田 一穂
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | De novo membranous nephropathy and antibody-mediated rejection in transplanted kidney. |
| Journal | Formal name：Clinical transplantation Abbreviation：Clin Transplant ISSN code：1399-0012(Electronic)0902-0063(Linking) |
| Volume, Issue, Page | 25(2),pp.191-200 |
| Author and coauthor | Honda Kazuho†, Horita Shigeru, Toki Daisuke, Taneda Sekiko, Nitta Kosaku, Hattori Motoshi, Tanabe Kazunari, Teraoka Satoshi, Oda Hideaki, Yamaguchi Yutaka* |
| Authorship | Lead author |
| Publication date | 2010/07 |
| Summary | BACKGROUND:The etiology of de novo membranous nephropathy (MN) after kidney transplantation is still uncertain. Immunological response to various allograft antigens is speculated to be a candidate for the etiBACKGROUND:ology.METHODS:Seventeen patients with post-transplant de novo MN were studied clinically and pathologically in comparison with control post-transplant patients without MN. Double immunofluorescent staining was performed to identify the presence of donor-specific human leukocyte antigen (HLA) combined with IgG in the deposits on glomerular capillary walls.RESULTS:De novo MN occurs in relatively late period after transplantation (102.1 ± 68.3 months), presenting various degree of proteinuria. Histological findings associated with antibody-mediated rejection (AMR), such as peritubular capillaritis and C4d deposition in peritubular capillary, were more frequently observed in the patients with de novo MN than the non-MN control patients. Donor-specific antibody (DSA) was detected in five patients at the time of biopsy. In one case of de novo MN with DSA, a donor-derived HLA was identified in the subepithelial deposits on the glomerular capillary walls combined with IgG deposition.CONCLUSIONS:DSA and AMR might play some roles for the pathogenesis in some patients with de novo MN after kidney transplantation. |
| DOI | 10.1111/j.1399-0012.2010.01213.x |
| Document No. | 20236137 |