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Maru Yoshiro
Department School of Medicine, School of Medicine Position Professor and Division head |
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| Article types | Review article |
| Language | English |
| Peer review | Peer reviewed |
| Presence of invitation | Invited paper |
| Title | Premetastasis. |
| Journal | Formal name：Cold Spring Harbor perspectives in medicine Abbreviation：Cold Spring Harb Perspect Med ISSN code：21571422/21571422 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | pp.a036897 |
| Author and coauthor | Maru Yoshiro |
| Authorship | Lead author,Corresponding author |
| Publication date | 2020/11 |
| Summary | Sterile inflammation within primary tumor tissues can spread to distant organs that are devoid of tumor cells. This happens in a manner dependent on tumor-led secretome, before the actual metastasis occurs. The premetastatic microenvironment is established in this way and is at least partly regulated by hijacking the host innate immune system. The biological manifestation of premetastasis include increased vascular permeability, cell mobilization via the blood stream, degradation of the extracellular matrix, immunosuppression, and host antineoplastic activities. |
| DOI | 10.1101/cshperspect.a036897 |
| PMID | 31615874 |