マル　ヨシロウ   Maru Yoshiro   丸　義朗    所属   医学部 医学科    職種   教授・基幹分野長
論文種別	総説
言語種別	英語
査読の有無	査読あり
招待の有無	招待あり
表題	Premetastasis.
掲載誌名	正式名：Cold Spring Harbor perspectives in medicine 略　 称：Cold Spring Harb Perspect Med ISSNコード：21571422/21571422
掲載区分	国外
巻・号・頁	pp.a036897
著者・共著者	Maru Yoshiro
担当区分	筆頭著者,責任著者
発行年月	2020/11
概要	Sterile inflammation within primary tumor tissues can spread to distant organs that are devoid of tumor cells. This happens in a manner dependent on tumor-led secretome, before the actual metastasis occurs. The premetastatic microenvironment is established in this way and is at least partly regulated by hijacking the host innate immune system. The biological manifestation of premetastasis include increased vascular permeability, cell mobilization via the blood stream, degradation of the extracellular matrix, immunosuppression, and host antineoplastic activities.
DOI	10.1101/cshperspect.a036897
PMID	31615874