Babazono Tetsuya
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor and Division head
Article types Original article
Language English
Peer review Peer reviewed
Title A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.
Journal Formal name：PloS one
Abbreviation：PLoS One
ISSN code：(1932-6203)1932-6203(Linking)
Domestic / ForeginForegin
Volume, Issue, Page 13(12),pp.e0208654
Author and coauthor Taira Makiko, Imamura Minako, Takahashi Atsushi, Kamatani Yoichiro, Yamauchi Toshimasa, Araki Shin-Ichi, Tanaka Nobue, van Zuydam Natalie R, Ahlqvist Emma, Toyoda Masao, Umezono Tomoya, Kawai Koichi, Imanishi Masahito, Watada Hirotaka, Suzuki Daisuke, Maegawa Hiroshi, Babazono Tetsuya, Kaku Kohei, Kawamori Ryuzo, , Groop Leif C, McCarthy Mark I, Kadowaki Takashi, Maeda Shiro
Publication date 2018/12
Summary To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p < 1.0 × 10-4) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 × 10-10. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 × 10-10). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.
DOI 10.1371/journal.pone.0208654
PMID 30566433