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ババゾノ テツヤ
Babazono Tetsuya
馬場園 哲也 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes. |
| 掲載誌名 | 正式名：PloS one 略 称：PLoS One ISSNコード：(1932-6203)1932-6203(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 13(12),pp.e0208654 |
| 著者・共著者 | Taira Makiko, Imamura Minako, Takahashi Atsushi, Kamatani Yoichiro, Yamauchi Toshimasa, Araki Shin-Ichi, Tanaka Nobue, van Zuydam Natalie R, Ahlqvist Emma, Toyoda Masao, Umezono Tomoya, Kawai Koichi, Imanishi Masahito, Watada Hirotaka, Suzuki Daisuke, Maegawa Hiroshi, Babazono Tetsuya, Kaku Kohei, Kawamori Ryuzo, , Groop Leif C, McCarthy Mark I, Kadowaki Takashi, Maeda Shiro |
| 発行年月 | 2018/12 |
| 概要 | To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p < 1.0 × 10-4) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 × 10-10. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 × 10-10). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes. |
| DOI | 10.1371/journal.pone.0208654 |
| PMID | 30566433 |