Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Endowed Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Long-term clinical course after catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy.
Journal Formal name:Heart and vessels
Abbreviation:Heart Vessels
ISSN code:0910-8327/1615-2573
Domestic / ForeginDomestic
Publisher Springer Japan KK
Volume, Issue, Page 34(3),pp.527-537
Author and coauthor HIGUCHI Satoshi†, EJIMA Koichiro*, MINAMI Yuichiro, OOYABU Kenjiro, IWANAMI Yuji, YAGISHITA Daigo, SHODA Morio, HAGIWARA Nobuhisa
Publication date 2019/03
Summary Atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) patients is highly associated with deterioration of their clinical condition, such as worsening heart failure symptoms, and an increased thromboembolic stroke risk and cardiac mortality rate. This study aimed to investigate the long-term clinical course after catheter ablation (CA) in HCM patients with AF. Among 566 primary HCM patients at our institution, 94 who underwent rhythm control therapy to manage AF from 2002 to 2016 were retrospectively analyzed. The eligible patients were divided into two groups: those who managed AF with CA (n = 34) and those without CA (n = 60). The endpoints were the incidence of initial clinical events, including HCM-related death or an unplanned heart failure hospitalization, or new-onset thromboembolic strokes. During a mean follow-up of 5.8 years, 6% in the CA group and 28% in the non-CA group had a progression of the AF type into permanent AF (Log-rank: p = 0.012). In the Kaplan-Meyer curve analyses, the incidence of clinical events was significantly lower in the CA group than non-CA group (p = 0.025). The annual rates for the incidence of clinical events were 1.2% in the CA group and 6.7% in the non-CA group. In a Cox multivariate analysis, CA therapy (adjusted hazard ratio 0.22; 95% confidence interval: 0.05-0.97; p = 0.046) was the only independent predictor of the incidence of clinical events. In conclusion, CA may be associated with a favorable long-term clinical course in HCM patients with AF.
DOI 10.1007/s00380-018-1269-3
PMID 30255478