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コンドウ ミツコ
KONDO Mitsuko
近藤 光子 所属 医学部 医学科（東京女子医科大学病院） 職種 特任教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Coexistence of diffuse panbronchiolitis and asthma: reciprocity of neutrophilic and eosinophilic inflammation. |
| 掲載誌名 | 正式名：Respirology case reports 略 称：Respirol Case Rep ISSNコード：2051-3380(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 5(3),pp.e00232 |
| 著者・共著者 | TAKEYAMA Kiyoshi†, SHIMIZU Yuri, ISHII Masanobu, HARA Hiroko, KONDO Mitsuko, TAMAOKI Jun |
| 発行年月 | 2017/05 |
| 概要 | Diffuse panbronchiolitis (DPB) and asthma are obstructive airway diseases, the former being characterized by Th1-type and the latter by Th2-type airway inflammation. Differential diagnosis is often a problem, but coexistence has rarely been reported. A 76-year-old man with asthma was admitted to our hospital because of one-month history of dyspnoea on exertion with bilateral diffuse granular shadows. He also had a history of chronic sinusitis. Auscultation of the lungs showed coarse crackles and wheezes. Laboratory data revealed an elevated total serum immunoglobulin E and a high titre of cold agglutinin. Bronchoscopic evaluations of the shadows revealed compatible pathological findings in both DPB and asthma. Low-dose macrolide caused a prompt reduction of symptoms, along with improvements in radiographic findings and pulmonary functions, whereas the eosinophilic airway inflammation transiently worsened. When DPB and asthma coexist, the balance of Th1/Th2 immune response may be reciprocally altered by therapeutic intervention. |
| DOI | 10.1002/rcr2.232 |
| PMID | 28392920 |