Nitta Kosaku    Department   Other, Other    Position
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Relation of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and left atrial volume index to left ventricular function in chronic hemodialysis patients.
Journal	Formal name：Heart and vessels Abbreviation：Heart Vessels ISSN code：1615-2573(Electronic)0910-8327(Linking)
Volume, Issue, Page	26(4),pp.421-7
Author and coauthor	Yamazaki Mayuko†, Ogawa Tetsuya, Tamei Noriko, Ando Yoshitaka, Nitta Kosaku
Authorship	Last author
Publication date	2011/07
Summary	Cardiovascular disease is the major cause of death in hemodialysis (HD) patients. We investigated the relation of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and left atrial volume index (LAVi) to left ventricular function in chronic HD patients. A total of 117 patients were enrolled as subjects (74 men and 43 women). Echocardiography was performed to evaluate the left atrial volume index (LAVi) and left ventricular mass index (LVMI). Diastolic left ventricular function was estimated as E/E' by tissue Doppler imaging with cardiac ultrasonography. Serum NT-proBNP was measured at the time of echocardiographic measurements. Multiple regression analysis showed that LAVi (F = 24.372, p<0.0001) and E/E' (F = 23.473, p<0.0116) were significant predictors for serum NT-proBNP levels, and LVMI (F = 46.807, p<0.0001) was a best predictor for LAVi among associated factors. These findings suggest that serum NT-proBNP and LAVi are both good biomarkers for predicting the LV remodeling in chronic HD patients.
DOI	10.1007/s00380-010-0066-4
Document No.	21127887