Nobuhisa Hagiwara    Department   Other, Other    Position
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Nutritional status during hospitalization is associated with the long-term prognosis of patients with heart failure
Journal	Formal name：ESC heart failure. Abbreviation：ESC Heart Fail ISSN code：20555822
Domestic / Foregin	Foregin
Volume, Issue, Page	pp.1-11
Author and coauthor	Takada Takuma†, JUJO Kentaro*, Endo Keiko, Abe Takuro, Shirotani Shota, KIshihara Makoto, Endo Nana, Watanabe Shonosuke, SUZUKI Kazuhito, Yuichiro Minami, Nobuhisa Hagiwara
Publication date	2021/10/01
Summary	Aims The CONtrolling NUTritional status (CONUT) score represents the nutritional status of patients with heart failure (HF). Although high CONUT scores on admission are associated with increased risks of cardiovascular (CV) events in patients with HF, the impact of CONUT changes during hospitalization on their long-term prognosis is unclear. This study aimed to investigate the impact of CONUT score changes on the clinical outcomes of patients with HF after discharge. Methods and results This observational study included 1705 patients hospitalized with HF who were discharged alive. The patients were categorized depending on their CONUT scores at admission and discharge into persistently high, high at admission and normal at discharge, normal at admission and high at discharge, and persistently normal CONUT groups. The primary endpoint was a composite of CV death and readmission for HF after discharge. The primary endpoint occurred in 652 patients (38%) during the median 525 day follow-up period. Patients with persistently high CONUT scores had the highest composite endpoint rate (log-rank trend test: P < 0.001). After adjusting for covariates, the hazard ratio for the composite outcome was significantly lower for the patients with high CONUT scores at admission and normal CONUT scores at discharge than that for those with persistently high CONUT scores (hazard ratio: 0.69; 95% confidence interval: 0.49–0.98). Conclusions Nutritional status changes in patients with HF that occurred during hospitalization were associated with CV events after discharge. Improving the nutritional status of patients may improve their clinical outcomes.
DOI	https://doi.org/10.1002/ehf2.13629