Nobuhisa Hagiwara    Department   Other, Other    Position
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Papillary muscle ischemia on high-resolution cine imaging of nitrogen-13 ammonia positron emission tomography: Association with myocardial flow reserve and prognosis in coronary artery disease.
Journal	Formal name：Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Abbreviation：J Nucl Cardiol ISSN code：10713581/15326551
Domestic / Foregin	Foregin
Publisher	Springer
Volume, Issue, Page	pp.in press
Author and coauthor	NAKAO Risako†, NAGAO Michinobu*, YAMAMOTO Atsushi,, FUKUSHIMA Kenji, WATANABE Eri, SAKAI Shuji, HAGIWARA Nobuhisa
Authorship	Last author
Publication date	2020/06
Summary	BACKGROUND:The evaluation of papillary muscle (PM) perfusion through existing perfusion imaging, including single-photon emission computed tomography and magnetic resonance imaging, is not possible. Therefore, this study sought to investigate the detection of PM ischemia in coronary artery disease (CAD) using nitrogen-13 (N-13) ammonia positron emission tomography (NH3 PET) and its association with global myocardial flow reserve (MFR) and major adverse cardiac events (MACE).METHODS:Data of adenosine-stress NH3 PET for 263 consecutive patients with known or suspected CAD were retrospectively analyzed. PM ischemia was defined as the absence of PM accumulation under stress conditions and PM presence at rest on high-resolution cine imaging derived from PET-computed tomography scanner with time-of-flight technology. The primary outcome was MACE.RESULTS:Of 263 patients, 30 experienced mean follow-up period of 910 days (MACE), while 31 (11.8%) presented PM ischemia. Compared to patients without PM ischemia, those with PM ischemia reported a significantly lower global MFR and a significantly higher rate of MACE (P < .0001).CONCLUSION:NH3 PET enables the detection of PM ischemia in approximately 10% of patients with known or suspected CAD. PM ischemia is associated with reduced global MFR and is an important sign in predicting prognosis.
DOI	10.1007/s12350-020-02231-z
PMID	32566962