Nobuhisa Hagiwara    Department   Other, Other    Position
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Self-Reported Non-adherence to Medication in Japanese Patients with Cardiovascular Diseases.
Journal	Formal name：American journal of cardiovascular drugs : drugs, devices, and other interventions Abbreviation：Am J Cardiovasc Drugs ISSN code：1179-187X/1175-3277
Domestic / Foregin	Foregin
Publisher	Springer Nature
Volume, Issue, Page	18(4),pp.311-316
Author and coauthor	SUZUKI Tsuyoshi†, SHIGA Tsuyoshi*, OMORI Hisako, TATSUMI Fujio, NISHIMURA Katsuji, HAGIWARA Nobuhisa
Authorship	Last author
Publication date	2018/08
Summary	OBJECTIVE:Non-adherence to medication is an important problem in cardiovascular treatment. The aim of this study was to assess self-reported non-adherence in Japanese patients with cardiovascular disease. METHODS:A total of 1372 outpatients at three university hospitals who completed self-reported questionnaires were analyzed in this prospective study (mean age 67 ± 12 years; 31% female). Self-reported adherence to cardiovascular drugs was measured with a modified Siegal scale. Depressive symptoms were defined as a Patient Health Questionnaire-9 score of ≥ 10. RESULTS:A total of 227 patients (17%) were defined as non-adherent. Multiple logistic regression analysis showed that ≥ 2 times daily dosing frequency, age < 65 years and active employment were significantly associated with non-adherence, with odds ratios of 4.42 [95% confidence interval (CI) 3.02-6.48], 1.70 (95% CI 1.23-2.35) and 1.43 (95% CI 1.03-1.99), respectively. However, depression was not a significant factor in non-adherence. CONCLUSIONS:Our study showed that self-reported non-adherence to medications was 17% in Japanese patients with cardiovascular disease in the university hospital setting. Daily dosing frequency, younger age and employment were significantly associated with non-adherence.
DOI	10.1007/s40256-018-0278-z
PMID	29748918