Nobuhisa Hagiwara
Department Other, Other Position |
|
Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Evaluation of the association between sleep apnea and polyunsaturated fatty acids profiles in patients after percutaneous coronary intervention. |
Journal | Formal name:Heart and vessels Abbreviation:Heart Vessels ISSN code:09108327/16152573 |
Domestic / Foregin | Foregin |
Publisher | Springer Japan |
Volume, Issue, Page | 32(11),pp.1296-1303 |
Author and coauthor | NAKABAYASHI Keisuke†, JUJO Kentaro*, SAITO Katsumi, OKA Toshiaki, HAGIWARA Nobuhisa |
Authorship | Last author |
Publication date | 2017/06 |
Summary | The long-term outcome is poor in patients with sleep apnea and cardiovascular disease. Polyunsaturated fatty acid (PUFA) is also known as an independent predictor for adverse clinical events. However, the profle of PUFA in sleep apnea patients with coronary artery disease (CAD) is still unclear. This study aimed to clarify the association between sleep apnea and PUFA profles in patients with CAD. Two hundred seventy-four consecutive patients undergoing percutaneous coronary intervention (PCI) were screened for sleep apnea using nocturnal oximetry. Oxygen desaturation index down to 4% (4%ODI) ≥5 was used as an indicator of sleep apnea. Baseline characteristics, including PUFA profles, were compared between patients with and without sleep apnea. Among 243 enrolled patients, 134 (55%) had sleep apnea. The sleep apnea group included a signifcantly higher rate of patients with obesity, insulinrequiring diabetes, peripheral artery disease (PAD), and a higher C-reactive protein level than the non-sleep apnea group. The sleep apnea group had a signifcantly lower eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio than the non-sleep apnea group (0.33 vs. 0.44, respectively, p = 0.024). Additionally, EPA value and EPA/AA ratio were signifcantly correlated with 4%ODI (r = −0.15, p = 0.028; r = −0.16, p = 0.019, respectively). Results of logistic regression analysis indicated that the comorbidities of obesity, PAD, heart failure and EPA/AA ratio had a signifcant association with sleep apnea. Our results suggested that patients with sleep apnea who underwent PCI had a lower EPA/AA ratio than those without sleep apnea, and EPA value and EPA/AA ratio were signifcantly correlated with 4%ODI. |
DOI | 10.1007/s00380-017-1010-7 |
PMID | 28631078 |