SHINICHI NUNODA    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor (Fixed Term)
Article types	Review article
Language	English
Peer review	Peer reviewed
Title	Impact of pretransplant antibodies on outcomes after heart transplantation.
Journal	Formal name：Current opinion in organ transplantation Abbreviation：Curr Opin Organ Transplant ISSN code：1087-2418/1531-7013
Domestic / Foregin	Foregin
Publisher	Wolters Kluwer
Volume, Issue, Page	24(3),pp.220-226
Author and coauthor	NUNODA Shinichi†
Authorship	Lead author
Publication date	2019/06
Summary	PURPOSE OF REVIEW: Since the discovery of human leukocyte antigen (HLA) in the 1950s, there has been great interest in the role of antibodies in posttransplant rejection. The development of the lymphocyte toxicity test by Terasaki et al. in the 1960s was the first step toward understanding the role of antibodies in posttransplant rejection. RECENT FINDINGS: Subsequently, various organs have been transplanted and improving posttransplant outcomes have become a focus of research. In particular, methods to measure antibodies that affect posttransplant outcomes, including anti-HLA antibodies, and methods to desensitize patients from specific antibodies have been explored. One recent method for measuring antibodies is called the solid-phase assay, which uses purified HLA fixed to microbeads. This assay does not use donor lymphocytes and allows clinicians to test the reactivity of patient serum against a panel of antibodies. It has also enabled the identification of specific anti-HLA antibodies using a single HLA. SUMMARY: In addition to advances in methods to measure and analyze anti-HLA antibodies, the clinical impact of non-HLA antibodies has also received much attention recently.
DOI	10.1097/MOT.0000000000000629
PMID	31090627