ヌノダ シンイチ   SHINICHI NUNODA
  布田 伸一
   所属   医学部 医学科(東京女子医科大学病院)
   職種   教授
論文種別 総説
言語種別 英語
査読の有無 査読あり
表題 Impact of pretransplant antibodies on outcomes after heart transplantation.
掲載誌名 正式名:Current opinion in organ transplantation
略  称:Curr Opin Organ Transplant
ISSNコード:1087-2418/1531-7013
掲載区分国外
出版社 Wolters Kluwer
巻・号・頁 24(3),220-226頁
著者・共著者 NUNODA Shinichi†
発行年月 2019/06
概要 PURPOSE OF REVIEW: Since the discovery of human leukocyte antigen (HLA) in the 1950s, there has been great interest in the role of antibodies in posttransplant rejection. The development of the lymphocyte toxicity test by Terasaki et al. in the 1960s was the first step toward understanding the role of antibodies in posttransplant rejection.

RECENT FINDINGS: Subsequently, various organs have been transplanted and improving posttransplant outcomes have become a focus of research. In particular, methods to measure antibodies that affect posttransplant outcomes, including anti-HLA antibodies, and methods to desensitize patients from specific antibodies have been explored. One recent method for measuring antibodies is called the solid-phase assay, which uses purified HLA fixed to microbeads. This assay does not use donor lymphocytes and allows clinicians to test the reactivity of patient serum against a panel of antibodies. It has also enabled the identification of specific anti-HLA antibodies using a single HLA.

SUMMARY: In addition to advances in methods to measure and analyze anti-HLA antibodies, the clinical impact of non-HLA antibodies has also received much attention recently.
DOI 10.1097/MOT.0000000000000629
PMID 31090627