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SHINICHI NUNODA
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor (Fixed Term) |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Evaluation of cardiac allograft vasculopathy by multidetector computed tomography and whole-heart magnetic resonance coronary angiography. |
| Journal | Formal name：Circulation journal : official journal of the Japanese Circulation Society Abbreviation：Circ J ISSN code：13469843/13474820 |
| Domestic / Foregin | Domestic |
| Publisher | The Japanese Circulation Society |
| Volume, Issue, Page | 74(5),pp.946-953 |
| Author and coauthor | NUNODA Shinichi†*, MACHIDA Haruhiko, SEKIKAWA Akihiko, SHITAKURA Kazunobu, OKAJIMA Kiyotaka, KUBO Yutaka, UENO Eiko, OTSUKA Kuniaki |
| Authorship | Lead author,Corresponding author |
| Publication date | 2010/05 |
| Summary | BACKGROUND:
Cardiac allograft vasculopathy (CAV) is a major complication that limits the long-term survival of recipients of heart transplants. In the present study the feasibility of 2 noninvasive approaches for detecting CAV (multidetector computed tomography (MDCT) and whole-heart magnetic resonance coronary angiography (MRCA)) was compared with conventional coronary angiography (CCAG). METHODS AND RESULTS: Of 22 heart transplant recipients who underwent CCAG screening, 13 had only MDCT, 16 had only MRCA, and 7 had both noninvasive modalities. The coronary arterial tree was divided into 9 segments. Detection of vasculopathy by coronary segments was compared between 16-/64-detector computed tomography (CT) or MRCA and CCAG. The sensitivity of both 16- and 64-detector CT for diagnosing CAV was 69.6%, and specificity was 96.8%. The sensitivity and specificity by 64-detector CT alone were 90.0% and 97.5%, respectively; its positive and negative predictive values were 81.8% and 98.7% respectively. For MRCA, sensitivity was 60%, specificity, 100%, positive predictive value, 100% and negative predictive value, 92.2%. MRCA showed no false positives. CONCLUSIONS: MDCT, especially 64-detector CT, is feasible for detecting CAV, whereas MRCA currently shows limited sensitivity. |
| DOI | 10.1253/circj.cj-09-0800 |
| PMID | 20215697 |