オダ ヒデアキ   ODA Hideaki
  小田 秀明
   所属   医学部 医学科
   職種   教授・講座主任
論文種別 原著
言語種別 英語
査読の有無 査読なし
表題 De novo membranous nephropathy and antibody-mediated rejection in transplanted kidney.
掲載誌名 正式名:Clinical transplantation
略  称:Clin Transplant
ISSNコード:1399-0012(Electronic)0902-0063(Linking)
巻・号・頁 25(2),191-200頁
著者・共著者 Honda Kazuho†, Horita Shigeru, Toki Daisuke, Taneda Sekiko, Nitta Kosaku, Hattori Motoshi, Tanabe Kazunari, Teraoka Satoshi, Oda Hideaki, Yamaguchi Yutaka*
発行年月 2010/07
概要 BACKGROUND:The etiology of de novo membranous nephropathy (MN) after kidney transplantation is still uncertain. Immunological response to various allograft antigens is speculated to be a candidate for the etiBACKGROUND:ology.METHODS:Seventeen patients with post-transplant de novo MN were studied clinically and pathologically in comparison with control post-transplant patients without MN. Double immunofluorescent staining was performed to identify the presence of donor-specific human leukocyte antigen (HLA) combined with IgG in the deposits on glomerular capillary walls.RESULTS:De novo MN occurs in relatively late period after transplantation (102.1 ± 68.3 months), presenting various degree of proteinuria. Histological findings associated with antibody-mediated rejection (AMR), such as peritubular capillaritis and C4d deposition in peritubular capillary, were more frequently observed in the patients with de novo MN than the non-MN control patients. Donor-specific antibody (DSA) was detected in five patients at the time of biopsy. In one case of de novo MN with DSA, a donor-derived HLA was identified in the subepithelial deposits on the glomerular capillary walls combined with IgG deposition.CONCLUSIONS:DSA and AMR might play some roles for the pathogenesis in some patients with de novo MN after kidney transplantation.
DOI 10.1111/j.1399-0012.2010.01213.x
文献番号 20236137