ツカハラ フジコ
  塚原 富士子
   所属   医学部 医学科
   職種   特任教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Nuclear export of the influenza virus ribonucleoprotein complex: Interaction of Hsc70 with viral proteins M1 and NS2.
掲載誌名 正式名:FEBS open bio
略  称:FEBS Open Bio
ISSNコード:(2211-5463)2211-5463(Linking)
掲載区分国外
巻・号・頁 4,pp.683-688
著者・共著者 Watanabe Ken, Shimizu Teppei, Noda Saiko, Tsukahara Fujiko, Maru Yoshiro, Kobayashi Nobuyuki*
発行年月 2014
概要 The influenza virus replicates in the host cell nucleus, and the progeny viral ribonucleoprotein complex (vRNP) is exported to the cytoplasm prior to maturation. NS2 has a nuclear export signal that mediates the nuclear export of vRNP by the vRNP-M1-NS2 complex. We previously reported that the heat shock cognate 70 (Hsc70) protein binds to M1 protein and mediates vRNP export. However, the interactions among M1, NS2, and Hsc70 are poorly understood. In the present study, we demonstrate that Hsc70 interacts with M1 more strongly than with NS2 and competes with NS2 for M1 binding, suggesting an important role of Hsc70 in the nuclear export of vRNP.
DOI 10.1016/j.fob.2014.07.004
PMID 25161876