ヤマナカ ヒサシ
  山中 寿
   所属   医学部 医学科(東京女子医科大学病院)
   職種   客員教授
論文種別 原著
言語種別 英語
査読の有無 査読なし
表題 Efficacy of Adalimumab in a Girl with Refractory Intestinal Behcet's Disease.
掲載誌名 正式名:Case reports in rheumatology
略  称:Case Rep Rheumatol
ISSNコード:(2090-6889)2090-6897(Linking)
掲載区分国外
巻・号・頁 2015,pp.716138
著者・共著者 Kaji Mariko, Kishi Takayuki, Miyamae Takako, Nagata Satoru, Yamanaka Hisashi, Fujikawa Satoshi
発行年月 2015
概要 We describe our experience with a juvenile patient who had refractory intestinal Behcet's disease that responded to adalimumab, a fully humanized antibody against soluble TNF-α and its receptor. The patient, a 13-year-old girl, presented with oral aphthous ulcers, vulvar pain, and rashes on the lower extremities. She gradually developed a low-grade fever, abdominal pain, diarrhea, and hematochezia. Lower gastrointestinal endoscopy revealed ulcers in the terminal ileum, consistent with intestinal Behcet's disease. Methylprednisolone pulse therapy was initiated, after which the symptoms transiently improved, but, during the corticosteroid taper, the abdominal pain recurred. The symptoms resolved soon after the administration of adalimumab. Of importance, the dose of corticosteroids was successfully reduced without exacerbation during 8 months of observation. This is the first reported case in which adalimumab was used for pediatric gastrointestinal Behcet's disease. Adalimumab is a good choice for intestinal Behcet's disease refractory to conventional treatment.
DOI 10.1155/2015/716138
PMID 26609459