菅野　仁    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor (Fixed Term)
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	A unique electrophoretic slow-moving glucose 6-phosphate dehydrogenase variant (G6PD Asahikawa) with a markedly acidic pH optimum.
Journal	Formal name：Human genetics Abbreviation：Hum Genet ISSN code：0340-6717(Print)0340-6717(Linking)
Volume, Issue, Page	68(1),pp.70-2
Author and coauthor	Takizawa T, Fujii H, Takegawa S, Takahashi K, Hirono A, Morisaki T, Kanno H, Oka R, Yoshioka H, Miwa S
Publication date	1984/09
Summary	A new glucose 6-phosphate dehydrogenase (G6PD) variant associated with chronic nonspherocytic hemolytic anemia was discovered in Japan. The patient showed hemolytic crises after upper respiratory infections. The enzyme activity was about 3.8% of the normal. The partially purified enzyme revealed slow anodal electrophoretic mobility, high Km NADP, marked thermal-instability, and increased affinity for a substrate analogue (deamino-NADP). A particular characteristic of this enzyme was a biphasic pH curve with a greatly increased activity at low pH values. From these results, this variant was clearly different from hitherto observed G6PD variants, and was designated G6PD Asahikawa.
Document No.	6500558