菅野　仁    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor (Fixed Term)
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Genetic analysis of adenosine deaminase expression in adult T-cell leukemia.
Journal	Formal name：American journal of hematology Abbreviation：Am J Hematol ISSN code：0361-8609(Print)0361-8609(Linking)
Volume, Issue, Page	28(2),pp.119-21
Author and coauthor	Morisaki T, Horiuchi N, Tsutsumi H, Ogura H, Kanno H, Tani K, Fujii H, Miwa S
Publication date	1988/06
Summary	We investigated the genetic basis for the increased adenosine deaminase (ADA) expression in adult T-cell leukemia (ATL). We found a correlation between the levels of ADA-specific mRNA and ADA immunoreactive protein in ATL. Southern blot analysis revealed no gene amplification or rearrangement of the ADA gene. These findings indicate that increased ADA expression in ATL cells reflects increased transcriptional activity for the ADA gene or increased stability of ADA mRNA.
Document No.	2456011