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菅野 仁
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor (Fixed Term) |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | A single nucleotide substitution in the phosphoglycerate kinase (PGK)-1 gene occurred after the separation of PGK-1 and PGK-2. |
| Journal | Formal name：Human genetics Abbreviation：Hum Genet ISSN code：0340-6717(Print)0340-6717(Linking) |
| Volume, Issue, Page | 89(5),pp.583 |
| Author and coauthor | Fujii H, Kanno H, Hirono A, Miwa S |
| Authorship | 2nd author |
| Publication date | 1992/07 |
| Summary | The mammalian genome contains two functional loci for the production of phosphoglycerate kinase, PGK-1, an X-linked gene expressed in all somatic cells, and PGK-2, an autosomal intron-less gene expressed exclusively in late spermatogenesis. A nucleotide substitution from guanine to thymine was recently found at position 473 of PGK-1 mRNA in PGK Shizuoka. The mutation was not found in the PGK-2 gene and might have occurred after separation of PGK-1 and PGK-2. |
| Document No. | 1634238 |