菅野　仁    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor (Fixed Term)
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Carbamazepine-induced hemolytic and aplastic crises associated with reduced glutathione peroxidase activity of erythrocytes.
Journal	Formal name：International journal of hematology Abbreviation：Int J Hematol ISSN code：0925-5710(Print)0925-5710(Linking)
Volume, Issue, Page	86(4),pp.325-8
Author and coauthor	Yamamoto Masaki, Suzuki Nobuhiro, Hatakeyama Naoki, Kubo Noriaki, Tachi Nobutada, Kanno Hitoshi, Fujii Hisaichi, Tsutsumi Hiroyuki
Publication date	2007/11
Summary	Although pure red cell aplasia is a well-known side effect of carbamazepine treatment, intravascular hemolytic anemia is rare. We describe a 5-year-old boy who developed concurrent intravascular hemolytic anemia and erythroblastopenia, probably due to carbamazepine. Carbamazepine treatment was subsequently discontinued, and the patient was treated with red blood cell transfusions, haptoglobin, and methylprednisolone. His hematologic abnormalities were almost fully recovered within 2 weeks. Examination of the patient's and mother's erythrocyte enzyme activities revealed mildly decreased erythrocyte glutathione peroxidase (GSH-Px) activity. We speculate that patients with reduced GSH-Px activity are at a high risk of developing carbamazepine-induced hemolytic crisis and/or aplastic crisis.
DOI	10.1532/IJH97.07027
Document No.	18055338