カンノ　ヒトシ   菅野　仁    所属   医学部 医学科（東京女子医科大学病院）    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Carbamazepine-induced hemolytic and aplastic crises associated with reduced glutathione peroxidase activity of erythrocytes.
掲載誌名	正式名：International journal of hematology 略　 称：Int J Hematol ISSNコード：0925-5710(Print)0925-5710(Linking)
巻・号・頁	86(4),pp.325-8
著者・共著者	Yamamoto Masaki, Suzuki Nobuhiro, Hatakeyama Naoki, Kubo Noriaki, Tachi Nobutada, Kanno Hitoshi, Fujii Hisaichi, Tsutsumi Hiroyuki
発行年月	2007/11
概要	Although pure red cell aplasia is a well-known side effect of carbamazepine treatment, intravascular hemolytic anemia is rare. We describe a 5-year-old boy who developed concurrent intravascular hemolytic anemia and erythroblastopenia, probably due to carbamazepine. Carbamazepine treatment was subsequently discontinued, and the patient was treated with red blood cell transfusions, haptoglobin, and methylprednisolone. His hematologic abnormalities were almost fully recovered within 2 weeks. Examination of the patient's and mother's erythrocyte enzyme activities revealed mildly decreased erythrocyte glutathione peroxidase (GSH-Px) activity. We speculate that patients with reduced GSH-Px activity are at a high risk of developing carbamazepine-induced hemolytic crisis and/or aplastic crisis.
DOI	10.1532/IJH97.07027
文献番号	18055338