カンノ　ヒトシ   菅野　仁    所属   医学部 医学科（東京女子医科大学病院）    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	An SNP in CYP39A1 is associated with severe neutropenia induced by docetaxel.
掲載誌名	正式名：Cancer chemotherapy and pharmacology 略　 称：Cancer Chemother Pharmacol ISSNコード：1432-0843
巻・号・頁	69(6),pp.1617-24
著者・共著者	Uchiyama Toshitaka, Kanno Hitoshi, Ishitani Ken, Fujii Hisaichi, Ohta Hiroaki, Matsui Hideo, Kamatani Naoyuki, Saito Kayoko
担当区分	2nd著者,責任著者
発行年月	2012/06
概要	PURPOSE:Docetaxel is one of the most widely used chemotherapy drugs for gynecological cancers. A dose-limiting factor of docetaxel is severe neutropenia, and previous reports showed that grade 4 neutropenia was observed in approximately 70% of Japanese patients treated with docetaxel. In order to elucidate a valid biomarker for docetaxel-induced neutropenia, we analyzed 42 Japanese patients with gynecological cancers such as ovarian cancer and endometrial cancer of the uterus.METHODS:As a first step, AUC of docetaxel was examined in 10 patients and 1,936 SNPs of 225 genes were genotyped using DMET Plus™ genotyping systems.RESULTS:The first screening revealed that 28 SNPs were associated with the AUC (PRESULTS:<RESULTS:0.05), and we analyzed the associations between the 28 SNPs and neutrophil counts in the other 32 patients, with the result that CYP39A1 (rs7761731) was found to be the only SNP significantly associated (P = 0.049RESULTS:OR = 9.0) with the incidence of grade 4 neutropenia among 28 SNPs.CONCLUSIONS:This SNP in CYP39A1 may be a useful biomarker for predicting the risk of docetaxel-induced neutropenia.
DOI	10.1007/s00280-012-1872-4
文献番号	22562553