シミズ　キヨウコ   SHIMIZU Kyoko   清水　京子    所属   その他 その他    職種   非常勤嘱託
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Impact of Renal Function on S-1 + Radiotherapy for Locally Advanced Pancreatic Cancer: An Integrated Analysis of Data From 2 Clinical Trials.
掲載誌名	正式名：Pancreas 略　 称：Pancreas ISSNコード：15364828/08853177
掲載区分	国外
巻・号・頁	50(7),pp.965-971
著者・共著者	Kobayashi Satoshi, Ueno Makoto, Ogawa Gakuto, Fukutomi Akira, Ikeda Masafumi, Okusaka Takuji, Sato Tosiya, Ito Yoshinori, Kadota Tomohiro, Ioka Tatsuya, Sugimori Kazuya, Sata Naohiro, Nakamori Shoji, Shimizu Kyoko, Mizuno Nobumasa, Ishii Hiroshi, Furuse Junji
発行年月	2021/08
概要	OBJECTIVES:S-1 monotherapy with concurrent radiotherapy (RT) is a standard of care for patients with locally advanced pancreatic cancer (LAPC). Although renal dysfunction increases S-1 monotherapy toxicity, its effect in S-1 with concurrent RT remains unknown. We evaluated the effect of renal function on the safety of S-1 with RT for LAPC.METHODS:We performed an integrated exploratory post hoc analysis of data from 2 prospective studies (JCOG1106 and LAPC-S1RT), where patients with LAPC received RT (50.4 Gy/28 fraction for 5.5 weeks) and concurrent S-1 (40 mg/m2 per dose, twice daily on the day of irradiation). We split the patients into high creatinine clearance (CCr; ≥80 mL/min) and low CCr (<80 mL/min) groups and compared the findings to determine treatment safety.RESULTS:The high and low CCr groups showed a median of 97.5 (range, 80.0-194.6) and 64.4 (range, 50.0-78.3) mL/min, respectively. The low CCr group presented more adverse reactions (ARs) of grade 3 or higher and gastrointestinal ARs of grade 2 or higher than the high CCr group (30.8% vs 15.8% and 51.9% vs 36.8%).CONCLUSIONS:The incidence of ARs associated with concurrent S-1 and RT increases in patients with low CCr; therefore, ARs should be duly considered in such patients.
DOI	10.1097/MPA.0000000000001879
PMID	34629456