シミズ　キヨウコ   SHIMIZU Kyoko   清水　京子    所属   その他 その他    職種   非常勤嘱託
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prospective study of early chronic pancreatitis diagnosed based on the Japanese diagnostic criteria.
掲載誌名	正式名：Journal of gastroenterology 略　 称：J Gastroenterol ISSNコード：14355922/09441174
巻・号・頁	54(10),pp.928-935
著者・共著者	Masamune Atsushi†, Nabeshima Tatsuhide, Kikuta Kazuhiro, Hamada Shin, Nakano Eriko, Kume Kiyoshi, Kanno Atsushi, Sato Ai, Tachibana Yuichi, Inatomi Osamu, Yamamoto Satoshi, Ikeura Tsukasa, Futagami Seiji, Taguchi Masashi, Hanada Keiji, Shimizu Kyoko, Kageoka Masanobu, Saito Tomotaka, Eguchi Takaaki, Kubota Kensuke, Takenaka Mamoru, Mima Atsushi, Irisawa Atsushi, Ito Tetsuhide, Andoh Akira, Inui Kazuo, Takeyama Yoshifumi, Yamaue Hiroki, Okazaki Kazuichi, Shimosegawa Tooru
発行年月	2019/10
概要	BACKGROUND:Chronic pancreatitis (CP) is a fibro-inflammatory disease of the pancreas. Early diagnosis and intervention, before CP becomes established and irreversible, are essential to improve the long-term outcomes. The world's first diagnostic criteria for early CP were proposed in Japan in 2009, but their clinical utility remains elusive. This study aimed to clarify whether patients with early CP progress to definite CP.METHODS:This is a multicenter, prospective study. Patients diagnosed as having early CP according to the Japanese diagnostic criteria were prospectively followed for 2 years. Clinical profiles including symptoms, drinking and smoking status, laboratory data, imaging findings and treatments were analyzed.RESULTS:Among the 83 patients who completed the 2-year follow-up period, four (4.8%) patients progressed to definite CP. The diagnosis of 48 (57.8%) patients was unchanged, and that of 31 (37.3%) patients was downgraded. All the four progressive patients were male, alcohol-related, smokers (3 current and 1 ever), and continued drinking. Comparison of the clinical profiles between the progression group (n = 4) and non-progression group (n = 79) revealed that etiology (alcohol-related), smoking status and presence of acute pancreatitis episodes were associated with the progression to definite CP.CONCLUSIONS:The Japanese diagnostic criteria could identify some patients before the progression to definite CP, while the majority of the patients did not progress.TRIAL REGISTRATION NUMBER:UMIN000015992.
DOI	10.1007/s00535-019-01602-9
PMID	31270692