TSUCHIYA Ken
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor (Fixed Term)
Article types Original article
Language English
Peer review Non peer reviewed
Title Factors associated with early-onset intracranial aneurysms in patients with autosomal dominant polycystic kidney disease.
Journal Formal name：Journal of nephrology
Abbreviation：J Nephrol
ISSN code：17246059/11218428
Domestic / ForeginForegin
Volume, Issue, Page 37(4),pp.983-992
Author and coauthor Ushio Yusuke, Kataoka Hiroshi, Akagawa Hiroyuki, Sato Masayo, Manabe Shun, Kawachi Keiko, Makabe Shiho, Akihisa Taro, Seki Momoko, Teraoka Atsuko, Iwasa Naomi, Yoshida Rie, Tsuchiya Ken, Nitta Kosaku, Hoshino Junichi, Mochizuki Toshio
Publication date 2024/05
Summary BACKGROUND:Recently, the importance of attribute-based medicine has been emphasized. The effects of early-onset intracranial aneurysms on patients can be significant and long-lasting. Herein, we compared the factors associated with intracranial aneurysms in patients with autosomal dominant polycystic kidney disease (ADPKD) according to age categories (≥ 50 years, < 50 years).
RESULTS:Regarding the presence of intracranial aneurysm, significant interactions were identified between the age category (age ≥ 50 years), female sex (P = 0.0027 for the interaction) and hypertension (P = 0.0074 for the interaction). Female sex and hypertension were associated with intracranial aneurysm risk factors only in patients aged ≥ 50 years. The presence of intracranial aneurysm was significantly associated with chronic kidney disease (CKD) stages 4-5 (odds ratio [OR] = 3.87, P = 0.0007) and family history of intracranial aneurysm or subarachnoid hemorrhage (OR = 2.30, P = 0.0217) in patients aged < 50 years. For patients aged ≥ 50 years, in addition to the abovementioned factors [OR = 2.38, P = 0.0355 for CKD stages 4-5; OR = 3.49, P = 0.0094 for family history of intracranial aneurysm or subarachnoid hemorrhage], female sex (OR = 4.51, P = 0.0005), and hypertension (OR = 5.89, P = 0.0012) were also associated with intracranial aneurysm.
CONCLUSION:Kidney dysfunction and family history of intracranial aneurysm or subarachnoid hemorrhage are risk factors for early-onset intracranial aneurysm. Patients aged < 50 years with a family history of intracranial aneurysm or subarachnoid hemorrhage or with CKD stages 4-5 may be at an increased risk of early-onset intracranial aneurysm.
DOI 10.1007/s40620-023-01866-8
PMID 38315279