TSUCHIYA Ken    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor (Fixed Term)
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Transcriptional factors, Mafs and their biological roles.
Journal	Formal name：World journal of diabetes Abbreviation：World J Diabetes ISSN code：1948-9358(Electronic)1948-9358(Linking)
Volume, Issue, Page	6(1),pp.175-83
Author and coauthor	Tsuchiya Mariko†, Misaka Ryoichi, Nitta Kosaku, Tsuchiya Ken
Authorship	Last author
Publication date	2015/02
Summary	The Maf family of transcription factors is characterized by a typical bZip structure; these transcription factors act as important regulators of the development and differentiation of many organs and tissues, including the kidney. The Maf family consists of two subgroups that are characterized according to their structure: large Maf transcription factors and small Maf transcription factors. The large Maf subgroup consists of four proteins, designated as MAFA, MAFB, c-MAF and neural retina-specific leucine zipper. In particular, MAFA is a distinct molecule that has been attracting the attention of researchers because it acts as a strong transactivator of insulin, suggesting that Maf transcription factors are likely to be involved in systemic energy homeostasis. In this review, we focused on the regulation of glucose/energy balance by Maf transcription factors in various organs.
DOI	10.4239/wjd.v6.i1.175
Document No.	25685288