ツチヤ　ケン   TSUCHIYA Ken   土谷　健    所属   医学部 医学科（東京女子医科大学病院）    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Transcriptional factors, Mafs and their biological roles.
掲載誌名	正式名：World journal of diabetes 略　 称：World J Diabetes ISSNコード：1948-9358(Electronic)1948-9358(Linking)
巻・号・頁	6(1),pp.175-83
著者・共著者	Tsuchiya Mariko†, Misaka Ryoichi, Nitta Kosaku, Tsuchiya Ken
担当区分	最終著者
発行年月	2015/02
概要	The Maf family of transcription factors is characterized by a typical bZip structure; these transcription factors act as important regulators of the development and differentiation of many organs and tissues, including the kidney. The Maf family consists of two subgroups that are characterized according to their structure: large Maf transcription factors and small Maf transcription factors. The large Maf subgroup consists of four proteins, designated as MAFA, MAFB, c-MAF and neural retina-specific leucine zipper. In particular, MAFA is a distinct molecule that has been attracting the attention of researchers because it acts as a strong transactivator of insulin, suggesting that Maf transcription factors are likely to be involved in systemic energy homeostasis. In this review, we focused on the regulation of glucose/energy balance by Maf transcription factors in various organs.
DOI	10.4239/wjd.v6.i1.175
文献番号	25685288