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TSUCHIYA Ken
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor (Fixed Term) |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Proteinuria is a simple sign of systemic inflammation that leads to a poor prognosis in individuals affected with non-Hodgkin lymphoma. |
| Journal | Formal name：Clinical nephrology Abbreviation：Clin Nephrol ISSN code：0301-0430(Print)0301-0430(Linking) |
| Volume, Issue, Page | 82(1),pp.51-7 |
| Author and coauthor | Hara Masaki†, Ando Minoru, Maeda Yoshiharu, Tsuchiya Ken, Nitta Kosaku |
| Publication date | 2014/07 |
| Summary | BACKGROUND:The clinical significance of proteinuria has not been fully understood among patients who are affected with non-Hodgkin lymphoma (NHL).METHODS:A 1-year prospective cohort study was conducted to ascertain the association between proteinuria and mortality in 46 hospitalized NHL patients. Proteinuria was defined as persistent dipstick testMETHODS:>METHODS:= 1+, and the urinary protein creatinine ratio (UPCR),as a quantitative index of protein excretion, was measured simultaneously. A multivariable linear regression model was constructed to determine factors associated with UPCR. Statistical associations between proteinuria and time to mortality were analyzed using the Kaplan-Meier method and multivariable proportional hazards regression analysis, adjusted for covariates including disease severity, renal function, and serum interleukin-6(IL-6) concentration.RESULTS:The prevalence of proteinuriaRESULTS:was 15.2% in the NHL patients. UPCR was significantly associated with the serum IL-6 level (standardized beta = 0.360, p = 0.0440). The cumulative mortality was significantly higher in proteinuric patients than in non-proteinuric patients, with a graded relationship between the severity of UPCR and mortality. The mortality risk increased with increasing UPCR grade: the hazard ratio (95% confidence interval) was 4.90 (1.29 - 32.3) for UPCR 30 - 300 mg/gand 17.8 (2.84 - 150) for UPCRRESULTS:>RESULTS:300 mg/g, respectively, when UPCRRESULTS:<RESULTS:30 mg/g was set as the reference.CONCLUSIONS:Proteinuria is a simple sign of coexisting systemic inflammation due to NHL and a harbinger of a poor prognosis. |
| DOI | 10.5414/CN108132 |
| Document No. | 24887301 |