TANAKA Junji    Department   Other, Other    Position
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	A case of lung intravascular large B cell lymphoma developed with respiratory failure rescued by corticosteroid prior to definite diagnosis.
Journal	Formal name：Respiratory medicine case reports Abbreviation：Respir Med Case Rep ISSN code：22130071/22130071
Domestic / Foregin	Foregin
Volume, Issue, Page	37,pp.101625
Author and coauthor	TSUJI Mayoko†, KONDO Mitsuko, ONIZAWA Fumi, SHISHIME Osamu, MURAMATSU Soshi, MATSUO Yuka, SAKAI Shuji, TANAKA Junji, TAGAYA Etsuko
Publication date	2022
Summary	A 56-year-old man complained progressive dyspnea, fatigue and fever for one month. His chest CT exhibited faint ground-glass opacities, and the levels of serum LDH and soluble interleukin 2 receptor were markedly elevated. Positron emission tomography (PET) showed high uptake of 18-fluoro deoxy glucose (18FDG) only on both lungs. We performed transbronchial lung biopsies (TBLB) for the diagnosis. After bronchoscopy, he had prolonged hypoxemia. Because defects of 99m-Technetium macroaggregated albumin (99mTc-MAA) in pulmonary blood flow scintigraphy were consistent with the distribution of 18FDG uptake in PET, we speculated that the presence of intravascular lymphoma (IVL) cells in the capillaries might have behaved like tumor embolism. We started rescue by prednisolone based on treatment of lymphoma. As a result, his hypoxemia was gradually improved. Histological findings in TBLB specimen showed that CD20+CD79+Bcl-2+c-myc+ lymphoma cells were localized to small vessel lumina in alveoli and bronchioles, and he was definitely diagnosed with lung intravascular large B cell lymphoma (IVLBCL). He was treated with complete cyclophosphamide, doxorubicin, vincristine, and prednisolone with rituximab (R-CHOP) in combination with intrathecal methotrexate injection. After eight cycles of R-CHOP and three times of intrathecal methotrexate, 18FDG uptake of PET on both lungs completely disappeared, achieving complete metabolic remission. We experienced a rare case of lung IVLBCL developed with respiratory failure successfully rescued by prednisolone prior to definite diagnosis.
DOI	10.1016/j.rmcr.2022.101625
PMID	35309974