タナカ ジユンジ
TANAKA Junji
田中 淳司 所属 その他 その他 職種 非常勤嘱託 |
|
論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Circulating cell-free DNA in the peripheral blood plasma of patients is an informative biomarker for multiple myeloma relapse. |
掲載誌名 | 正式名:International journal of clinical oncology 略 称:Int J Clin Oncol ISSNコード:14377772/13419625 |
掲載区分 | 国外 |
巻・号・頁 | 26(11),pp.2142-2150 |
著者・共著者 | Yasui Hiroshi†, Kobayashi Masayuki, Sato Kota, Kondoh Kanya, Ishida Tadao, Kaito Yuta, Tamura Hideto, Handa Hiroshi, Tsukune Yutaka, Sasaki Makoto, Komatsu Norio, Tanaka Norina, Tanaka Junji, Kizaki Masahiro, Kawamata Toyotaka, Makiyama Junya, Yokoyama Kazuaki, Imoto Seiya, Tojo Arinobu, Imai Yoichi |
発行年月 | 2021/11 |
概要 | BACKGROUND:Multiple myeloma (MM) is an incurable hematological malignancy. Despite the introduction of several novel drugs, most patients relapse. Biomarkers to identify the early signs of relapse will make it possible to adjust the therapeutic strategy before the disease worsens. Although understanding genetic changes is important for the treatment of MM, currently known biomarkers of relapse, including serum free-light chains and monoclonal paraproteins, are not associated with genetic changes.METHODS:We therefore performed a multicenter study to examine the usefulness of circulating cell-free DNA (cfDNA) present in the peripheral blood (PB) plasma of patients as a biomarker for MM relapse.RESULTS:We identified several driver mutations by combined analysis of next-generation sequencing and existing databases of candidate oncogenes. Furthermore, relapse was detected more sensitively by monitoring the circulating cfDNA with these driver mutations than by conventional serum free-light chain examination.CONCLUSION:These results suggest the potential utility of cfDNA in the PB plasma of patients as a relevant early biomarker for MM relapse. |
DOI | 10.1007/s10147-021-01991-z |
PMID | 34259983 |