タナカ ジユンジ   TANAKA Junji
  田中 淳司
   所属   医学部 医学科(東京女子医科大学病院)
   職種   教授・基幹分野長
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome in adolescent and young adult patients.
掲載誌名 正式名:Bone marrow transplantation
略  称:Bone Marrow Transplant
ISSNコード:14765365/02683369
掲載区分国外
巻・号・頁 56(10),pp.2510-2517
著者・共著者 Shimomura Yoshimitsu†, Hara Masahiko, Konuma Takaaki, Itonaga Hidehiro, Doki Noriko, Ozawa Yukiyasu, Eto Tetsuya, Uchida Naoyuki, Aoki Jun, Kato Jun, Onishi Yasushi, Takahashi Satoshi, Fukushima Kentaro, Nakamae Hirohisa, Kawakita Toshiro, Tanaka Junji, Fukuda Takahiro, Atsuta Yoshiko, Ishikawa Takayuki, Ishiyama Ken
発行年月 2021/10
概要 Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curable treatment option for adolescent and young adult (AYA) patients with myelodysplastic syndrome (MDS). The study aim was to evaluate epidemiological data and identify prognostic factors for AYA patients with MDS undergoing allogeneic HSCT. Here, 645 patients were selected from patients enrolled in a multicenter prospective registry for HSCT from 2000 to 2015. The primary endpoint was 3-year overall survival (OS). Survival rates were estimated using the Kaplan-Meier method. Prognostic factors were identified using the multivariable Cox proportional hazards model. The 3-year OS was 71.2% (95% confidence interval [CI]: 67.4-74.6%). In multivariable analysis, active disease status (adjusted hazard ratio: 1.54, 95% CI: 1.09-2.18, p = 0.016), poor cytogenetic risk (1.62, 1.12-2.36, p = 0.011), poor performance status (2.01, 1.13-3.56, p = 0.016), human leukocyte antigen (HLA)-matched unrelated donors (2.23, 1.39-3.59, p < 0.001), HLA-mismatched unrelated donors (2.16, 1.09-4.28, p = 0.027), and cord blood transplantation (2.44, 1.43-4.17, p = 0.001) were significantly associated with poor 3-year OS. In conclusion, in AYA patients with MDS the 3-year OS following allogeneic HSCT was 71.2%. Active disease status, poor cytogenetic risk, poor performance status, and donor sources other than related donors were associated with poor 3-year OS.
DOI 10.1038/s41409-021-01324-8
PMID 33993196