TANAKA Junji
   Department   Other, Other
   Position  
Article types Original article
Language English
Peer review Peer reviewed
Title Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors.
Journal Formal name：Bone marrow transplantation
Abbreviation：Bone Marrow Transplant
ISSN code：14765365/02683369
Domestic / ForeginForegin
Volume, Issue, Page 56(3),pp.646-654
Author and coauthor Morishima Satoko†, Fukuda Takahiro, Doki Noriko, Mori Takehiko, Onizuka Makoto, Kawakita Toshihiro, Kato Chiaki, Ozawa Yukiyasu, Tanaka Masatsugu, Kurokawa Mineo, Kamimura Tomohiko, Inoue Masami, Tanaka Junji, Ichinohe Tatsuo, Atsuta Yoshiko, Morishima Yasuo,
Publication date 2021/03
Summary In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Japanese registry, we retrospectively analyzed 4392 patients with leukemia or myelodysplastic syndrome who received transplants from HLA-identical sibling donors to investigate the effects of HLAs on acute GVHD. From unbiased searches of HLA-A, -B, and -DR, HLA-B60 was significantly associated with an increased risk of grades II-IV acute GVHD (HR, 1.34; 95% CI, 1.13-1.59; P = 0.001). In contrast, HLA-B62 was significantly associated with a decreased risk of grades II-IV (HR, 0.73; 95% CI, 0.62-0.87; P < 0.001) and III-IV acute GVHD (HR, 0.63; 95% CI, 0.46-0.87; P = 0.005). The risk of leukemia relapse was significantly higher in HLA-B62-positive patients than in HLA-B62-negative patients (HR, 1.23; 95% CI, 1.05-1.43; P = 0.01). Both HLA-B60 and -B62 did not affect overall survival. The findings of this study may by implication suggest the possibility that the effects of specific HLAs on transplant outcomes may reflect inherent biological features, and thus consideration of specific HLAs may be helpful to predict transplant outcomes.
DOI 10.1038/s41409-020-01070-3
PMID 33037403