タナカ ジユンジ   TANAKA Junji
  田中 淳司
   所属   医学部 医学科(東京女子医科大学病院)
   職種   教授・基幹分野長
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors.
掲載誌名 正式名:Bone marrow transplantation
略  称:Bone Marrow Transplant
ISSNコード:14765365/02683369
掲載区分国外
巻・号・頁 56(3),pp.646-654
著者・共著者 Morishima Satoko†, Fukuda Takahiro, Doki Noriko, Mori Takehiko, Onizuka Makoto, Kawakita Toshihiro, Kato Chiaki, Ozawa Yukiyasu, Tanaka Masatsugu, Kurokawa Mineo, Kamimura Tomohiko, Inoue Masami, Tanaka Junji, Ichinohe Tatsuo, Atsuta Yoshiko, Morishima Yasuo,
発行年月 2021/03
概要 In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Japanese registry, we retrospectively analyzed 4392 patients with leukemia or myelodysplastic syndrome who received transplants from HLA-identical sibling donors to investigate the effects of HLAs on acute GVHD. From unbiased searches of HLA-A, -B, and -DR, HLA-B60 was significantly associated with an increased risk of grades II-IV acute GVHD (HR, 1.34; 95% CI, 1.13-1.59; P = 0.001). In contrast, HLA-B62 was significantly associated with a decreased risk of grades II-IV (HR, 0.73; 95% CI, 0.62-0.87; P < 0.001) and III-IV acute GVHD (HR, 0.63; 95% CI, 0.46-0.87; P = 0.005). The risk of leukemia relapse was significantly higher in HLA-B62-positive patients than in HLA-B62-negative patients (HR, 1.23; 95% CI, 1.05-1.43; P = 0.01). Both HLA-B60 and -B62 did not affect overall survival. The findings of this study may by implication suggest the possibility that the effects of specific HLAs on transplant outcomes may reflect inherent biological features, and thus consideration of specific HLAs may be helpful to predict transplant outcomes.
DOI 10.1038/s41409-020-01070-3
PMID 33037403