タナカ ジユンジ   TANAKA Junji
  田中 淳司
   所属   医学部 医学科(東京女子医科大学病院)
   職種   教授・基幹分野長
論文種別 総説
言語種別 英語
査読の有無 査読あり
表題 Recent progress in and challenges in cellular therapy using NK cells for hematological malignancies.
掲載誌名 正式名:Blood reviews
略  称:Blood Rev
ISSNコード:15321681/0268960X
掲載区分国外
巻・号・頁 44,pp.100678
著者・共著者 Tanaka Junji†*, Miller Jeffrey S
担当区分 筆頭著者,責任著者
発行年月 2020/11
概要 NK cells have killing activity against leukemic cells and solid cancer cells that escape from T cell recognition because of the low expression level of HLA class I molecules. This characteristic feature of NK cell recognition of target cells in contrast to T cells provides a strategy to overcome tolerance in cancer and leukemia patients. A strong alloreactive NK cell-mediated anti-leukemia effect can be induced in haploidentical hematopoietic stem cell transplantation. Also, NK cells can be expanded by several methods for adoptive immunotherapy for hematological malignancies and other malignant diseases. We review the historical role of NK cells and recent approaches to enhance the functions of NK cells, including ex vivo expansion of autologous and allogenic NK cells, checkpoint receptor blockade, and the use of memory-like NK cells and CAR-NK cells, for treatment of hematological malignancies.
DOI 10.1016/j.blre.2020.100678
PMID 32229065